A new study by multinational scientists shows that vitamin B can play a crucial role in reducing the impact of air pollution on the epigenome. This research article further demonstrates the epigenetic impact of air pollution on health. This is the first detailed study to develop interventions to prevent or reduce the potential impact of air pollution. The results were published online on PNAS on March 13.
Scientists in the United States, Sweden, China, Singapore, Mexico, and Canada have demonstrated that individual-level prevention can be used to control the potential adverse effects of PM2.5 particulate matter. These findings have significant public health benefits in the frequent peak areas of PM2.5 particulate matter.
1. The harm of PM2.5 pollution
The WHO estimates that 92% of the world's population live in the air with PM2.5 levels exceeding the WHO limit of 10 μg/m3.
Environmental PM2.5 particulate matter is one of the most important air pollutants because they affect the respiratory tract, cause inflammation and poor stress. Although PM2.5 particulate matter pollution has decreased in the local environment through large-scale emission control policies in the past few decades, the adverse health consequences of exposure are still reported frequently.
2, methylation changes detect the role of vitamin B family
Acute exposure to PM2.5 particles can cause changes in DNA methylation and inflammation and oxidative stress. The researchers conducted a crossover trial to determine if B vitamins were added to avoid such changes.
The investigator gave a placebo or vitamin B supplement (2.5 mg of folic acid, 50 mg of vitamin B6 and 1 mg of vitamin B12) to each adult in the test. Volunteers participating in the test were asked to be healthy non-smokers, 18 to 60 years of age, without taking any medications or vitamin supplements. Volunteers participating in the test received two hours of PM2.5 (250 μg/m3) exposure.
The assay used Infinium human methylation 450 magnetic bead chips to test peripheral blood CD4+ T helper cells and analyze the methylation status of the epigenome before and after exposure. PM2.5 particles cause methylation changes in genes involved in mitochondrial oxidative energy metabolism. B vitamins can prevent these changes. Studies have shown that individual-level prevention can complement the potential damage pathways that regulate and control environmental PM2.5 particulate contamination.
3. The author's introduction to the research
Columbia University article Professor Andrea Baccarelli, senior director of environmental and health science at the Mailman School of Public Health, said: "The molecular basis of the health effects of air pollution is unclear, and there is a lack of choice at the individual level of prevention, which represents a gap in key knowledge. We conducted a series of studies to develop preventive interventions to minimize the adverse effects of air pollution on potential markers. Our findings are very important due to the central role of epigenetic modifications in mediating environmental impacts. May spread to other toxic and environmental diseases."
Jia Zhong, the first author and correspondent of the article, said, “The impact of air pollution on health and how it works has raised many complex issues in personal health. Even if we can solve this problem on a personal level, we are still far away. Far from completely solving the challenges of public health."
Professor Baccarelli added: “Although emissions control and regulation are the key to prevention and control, unfortunately many large cities around the world are still highly exposed. As individuals, our choice to protect ourselves from air pollution is limited. Future research, especially In areas with high levels of pollution, there is an urgent need to validate our findings and ultimately develop preventive measures that use B vitamins to affect the health of air pollution."
4, vitamin B family is very hot recently
High doses of vitamin B improve schizophrenia
For the first time, a new study found that in addition to these standard treatments, high doses of B vitamins may help reduce symptoms of schizophrenia more than traditional treatments. The new study was led by Joseph Firth of the Department of Psychology and Mental Health at the University of Manchester in the UK and published in the journal Psychological Medicine.
The study showed that high doses of B vitamins such as B-6, B-8 and B-12 can significantly reduce the symptoms of schizophrenia. In addition, the combined doses of several vitamins showed the same effect, but low doses of vitamins had no effect. At the same time, research and analysis showed that vitamin B was the best in the early stage of disease development. For patients with shorter illnesses, vitamin B is most effective.
Vitamin B3 treatment for glaucoma
Science reports cheap treatment for glaucoma: supplementation with vitamin B3
Professor Jackson WM John, a professor at the Jackson Laboratory in the United States and a researcher at the Howard Hughes Medical Institute, reported on their team's new findings on February 17th: mice that are genetically glaucoma-prone by adding vitamin B3 to drinking water. It has the effect of preventing disease.
In essence, the treatment of vitamin B3 (nicotinamide) can promote the stability of aging retinal ganglion cell metabolism, allowing them to stay healthy for a longer period of time. Experiments in mice have shown that taking vitamins is so strikingly effective that it eliminates most age-related molecular changes and provides a significant and powerful protection against glaucoma. It offers hope for the development of inexpensive and safe treatment for glaucoma patients.
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