The main plastic medicine packaging materials used in pharmaceutical packaging more types of plastic materials, including PVC, PE, PP, PS, PET, nylon and so on. Among them, PE, PP, and PET accounted for the largest proportion, and the amount of PVC was decreasing.
The main forms of plastic medicine packaging plastic aluminum composite bags, multi-layer plastic composite bags, blisters blister packaging, a variety of packaging solid, liquid medicine bottles and infusion bottles are the main form of pharmaceutical packaging. Among them, bubble eye blister packaging is becoming the most important solid drug packaging method. PP, PE and PET bottles are used in both solid and liquid medicines.
Liquid drug packaging liquid drugs are mainly divided into injections, large infusions and oral liquids. There are two types of liquid medicines: bottle and bag.
Plastic materials have made slow progress in injection packaging. Although it is widely believed that plastic bottles may replace Ampoules as the main form of injections in the future, due to concerns that components filtered out of plastics may contaminate the product, drug regulatory agencies in various countries are more prudent in managing plastics.
On the contrary, plastic packaging is making breakthrough progress in transfusion medicines. According to incomplete statistics, there are currently more than 200 infusion companies that have passed GMP certification, and the infusion production capacity is about 3 billion bottles. More than 100 companies have annual production capacity of more than 10 million bottles. Some of the large-scale infusion drug companies, including Shuanghe Pharmaceutical and Tianjin Daxuan, are using plastic bottles or bags for large infusion packaging.
Although glass bottles still account for more than 80% of China's total infusion packaging volume, the status quo is changing with the rapid development of polyolefin plastic bags and BOPP bottles in this area. Especially BOPP bottles, due to the advantages of high production, low unit cost, etc., due to the domestic production of equipment, are rapidly gaining popularity among domestic large infusion manufacturers. Since the BOPP bottle cannot be processed for secondary cleaning, the bottle must be produced in a GMP-certified factory building, and the storage conditions must also comply with GMP requirements. Polyolefin infusion bag production line has also introduced a lot of domestic, but due to polyolefin raw materials can not be produced domestically, resulting in higher costs, there are some difficulties in the field development, and the use of PVC bags will gradually shrink.
In the oral solution, soft plastic bottles have been partially applied, and gradually expand its application. Hard plastic bottles are also slowly replacing glass for packaging larger volumes of liquid drugs such as syrups, which is consistent with European developments. The main reason is that plastic containers often have a wide bottleneck and are easier to fill. The production process on the filling line is also faster, less broken and can provide a larger label area to carry more information.
The biggest disadvantage of plastics in liquid packaging is that the shelf life of pharmaceuticals is usually shortened when they are changed from glass to plastic bottles. Single-layer plastic containers have limited barrier properties, while composite plastic containers are subject to price constraints. One of the current trade-offs in Europe is the addition of a plastic shrink sleeve outside the glass bottle.
Solid medicines used in liquid medicine bottles are packed with solid medicines, including tablets, granules and powders. Plastic bags, plastic bottles and blister packs are their main forms of packaging.
Tablets are the largest variety and the largest volume of drugs sold. Large-capacity glass bottles are rapidly exiting the field and replaced by plastic bottles and aluminum-plastic blister packs.
The most common blister packs are made of polyvinyl chloride sheets (PVC) and composite double aluminum sheets (CFF). PVC sheets have good compatibility, are easy to form and seal, and are inexpensive, but have relatively low moisture barrier properties. CFF has good barrier properties against moisture, but it is easy to distort and can't see the inner medicine. Therefore, pills are rarely used.
In order to solve the problem of poor barrier property of PVC blister, and the high price of double aluminum blister, it is generally used to coat PVDC on PVC. Some companies have also developed films coated with fluorinated chloride resins on PVC to better improve barrier properties and transparency.
Since most drugs need to be stored in the dark, the white LDPE bottle is also the most commonly used drug package, and is particularly suitable for large doses of Chinese and Western medicine pills and tablets. A small amount of bottles are also made of transparent brown bottles as needed, and these bottles are mainly made of PET.
Bottle caps are also mostly made of PE or PP.
Aluminum-plastic composite bag has the advantages of good barrier property, simple processing, etc. It is widely used and is currently the main packaging form of Chinese and western medicine powder and granules.
Overall, China's solid pharmaceutical packaging bottles and bags can basically meet the needs of processing methods, the problem is how to ensure product health and safety.
The material for aluminum cap includes the pure aluminum, alloy aluminum, imported aluminum strip and homeâ€made aluminum strip; the aluminum strip is processed by coating the nontoxic epoxy resin before using, with sound property of heat resistance, filmâ€removing
resistance and discoloration after boiling at high temperature.
There are multiple sizes and types for the caps for liquidâ€infusion glass bottles. We are sincere to produce the easyâ€toâ€pull aluminum cap for ∅30, ∅32 infusion bottle, aluminumâ€plastic composite cap and aluminumâ€plastic pullâ€tab cap for ∅26, ∅28, ∅30 and∅32 liquidâ€infusion glass bottle, aluminumâ€plastic composite cap for∅36 infusion glass bottle (for blood product only), aluminumâ€plastic easyâ€toâ€pull cap for ∅32 infusion bottle (3â€piece) and other types; we are capable of producing on the demand of customers.
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YANGZHONG HONGYUN BOTTLE CAPS MAKING FACTORY , https://www.hongyunyz.com