On October 24th, according to foreign media reports, when Adam Feinberg tried to study how to synthesize human tissue four years ago, the materials he used were nothing special: a kitchen mixer, from the supermarket baking Some gelatin in the merchandise area, as well as a $2000 3D printer .
Feinberg, 38, said, "I didn't have external funding when I started this research, so we have to be careful." The biomedical engineer is currently in charge of a laboratory at Carnegie Mellon University.
In a recent paper published in Science Advances, Feinberg and colleagues describe how they can use technology to improve the use of proteins such as collagen and fibrin to print arterial tissue, brain and other organs. Structural replica. Although the replicas they create are not living cells that work well, they may act as a support for real tissue growth in the future.
Currently, doctors are already using 3D printing technology to support the baby's damaged trachea, creating a titanium alloy jaw bone substitute, and synthesizing a miniature liver to test potential drug therapies. There are still many obstacles to creating a customizable organ that can be used for transplantation. But the new research above makes the vision of customizing human tissue for therapeutic testing a step closer to reality.
Advances in fundamental research team Feinberg is to find ways to prevent changes after the MakerBot 3D printer to create a flexible structure from collapsing due to its own weight. Unlike plastics, collagen, a commonly used material for 3D printers, does not remain undeformed when synthesized, unless it has specific support.
The research team thought of how jelly molds use sugary gels to hold fruit pieces. They tested it with gelatin and incorporated it into a microparticle slurry. The slurry will support the printed layered structure without affecting the printer's nozzles (modified via the syringe). After the object is printed, it will be bonded to itself, and the supporting gelatin will melt due to heat.
University of Florida professor Tommy Angelini pointed out that the process is relatively simple and allows others to research on the basis of this innovation. His laboratory has recently published a similar study of organ manufacturing methods. He did not participate in Feinberg's research.
Creating an organ in an implantable patient remains a challenge for the future. Angelini said, "This will eventually be achieved, but there is still a long way to go, and there are many, many basic scientific issues to be solved."
In the near term, the above-mentioned new 3D printing technology may permit doctors to conduct therapeutic tests on laboratory replicas of organs in patients. Drug companies may use this model to test high-risk new drugs before they are used by humans.
"At the moment we have animal models - mice - we have clinical trials for humans, but not many." Feinberg said, "You may be able to make a myocardial replica of the patient."
Feinberg's research is funded by the National Institutes of Health and the National Science Foundation. However, he is still as careful as he was at the beginning. Although Carnegie Mellon applied for a patent on the above research, his team posted information telling other researchers how to modify the MakerBot printer to process biomaterials under an open source license. He also showed the bioprinting technology in a school – using chocolate icing instead of collagen.
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