Detection of changes in human metabolism during exercise

Researchers from Massachusetts General Hospital, Harvard Medical School, Beth Israel Deaconess Medical Center and others applied highly sensitive mass spectrometry to detect 200 types of blood in a group of participants before, during and after exercise on a treadmill Metabolites found a series of changes in the body's movement.

During exercise, the body undergoes changes in many aspects of metabolism. For example, fat is regulated by the nerve and endocrine system. Sympathetic nerves, adrenaline, glucagon, thyroxine, growth hormone, cortisol, etc. promote fat mobilization, while insulin inhibits effect. The body can make more use of plasma free fatty acids, triglycerides and ketone bodies during exercise, and can increase the storage of triglycerides in muscle cells.

But specifically, what happens to the chemical substances in the blood during this process, so far it is not clear, in this study, the researchers applied a highly sensitive mass spectrometry method to detect a group of participants running 200 metabolites in the blood before, during and after in-flight exercise. The results show that healthier individuals (whether due to innate health or become healthy through training) have different biochemistry in the bloodstream Changes, these changes allow them to burn more calories than those who are less healthy.

This study found chemical switches in the body. These chemical switches are obviously different in healthier people than in less healthy people during exercise. Sweating through exercise and accelerating the heartbeat are known to protect the body from many diseases and prolong lifespan, but it is still not clear why exercise has these absolutely positive effects. These findings give people a new understanding of how exercise affects metabolism, and may allow people to develop new diagnostic tests to assess a person's health and use the latest added substances to supplement the metabolites lost after exercise (think After a run, swallow the energy drink full of metabolites).

Every energy-using activity in the body causes the production of metabolites. Metabolites are those measured in the blood. They are derived from the metabolism or degradation of the original substance. Each blood sample contains hundreds of these metabolites, and on a certain day they can provide a chemical "snapshot" of a person's health.

This study shows that healthy individuals and unhealthy individuals have a distinct set of changes in metabolites. The researchers applied highly sensitive mass spectrometry to detect 200 metabolites in the blood of a group of participants before, during, and after exercising on the treadmill. They found that the disintegration of stored fat, sugar and amino acids in healthy people can increase by 98%, while the increase in unhealthy people is only 60-70%. In another group of very healthy people participating in the Boston Marathon, the increase can be as high as 1128%. These results show that healthier individuals (whether due to innate health or becoming healthy through training) have different biochemical changes in their bloodstream, and these changes allow them to burn more than those who are less healthy Many hot cards.

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